Lawrence Livermore National Laboratory

A Systems Biology Approach to Interactions and Resource Allocation in Bioenergy-Relevant Microbial Communities

The LLNL Biofuels Scientific Focus Area (SFA) is focused on the community systems biology of microbial consortia that are closely associated with bioenergy-relevant plants and algae, with the ultimate goal of developing predictive models. Photosynthetic algal and plant systems have the unrivaled advantage of converting solar energy and CO2 into useful organic molecules. Their growth and efficiency are largely shaped and assisted by their surrounding “microbiome”—the groups of microorganisms that dwell in and around plants and algae and live off photosynthate, exopolymers, or exudates. The biogeochemical outcomes of these interactions—how specific taxonomic combinations affect energy and nutrient cycling pathways and are shaped by various environmental stressors—are fundamental concerns in the fields of microbial ecology and bioenergy production.

We seek to understand and predict ecological, biophysical, and biochemical dynamics of multi-taxa communities, as well as the metabolite fluxes that regulate trophic interactions. In our research, we focus on microscale interactions between bacteria and algae in the phycosphere (the surface of algal cells) and between soil bacteria, fungi, and plant roots in the rhizosphere as model systems. Our approach emphasizes microbial ecology, organismal interactions, quantitative isotope tracing of elemental exchanges, and effects of environmental regulation, using techniques that exploit unique LLNL capabilities to measure the microscale impacts of single cells on system scale processes.

News Highlights

May 18, 2018

NanoSIMS image of copper and phosphorus signals in the zebrafish embryo retina, showing copper is enriched in puncta in the outer nuclear layer

New publication on multimodal LA-ICP-MS and nanoSIMS imaging

We are developing high sensitivity, high spatial resolution methods to image essential metals in biological systems.

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The LLNL greenhouse

Greenhouse at LLNL now open!

Our new greenhouse facility is now operational.

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Presenter with his powerpoint slide on the wall behind him.

Invited seminar on computational systems biology research

SFA team member Ali Navid recently gave an invited seminar as part of the LLNL’s and nearby Las Positas College student science and engineering seminar series.

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